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Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone
Cytosolic HSP90 requires multiple cochaperones in folding client proteins. However, the function of gp96 (HSP90b1, grp94), an HSP90 paralogue in the endoplasmic reticulum (ER), is believed to be independent of cochaperones. Here, we demonstrate that gp96 chaperones multiple Toll-like receptors (TLRs...
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| Autors principals: | , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2982182/ https://ncbi.nlm.nih.gov/pubmed/20865800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1070 |
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