Identification of the miR-106b∼25 MicroRNA Cluster as a Proto-Oncogenic PTEN-Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation

PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a tumor suppressor that antagonizes signaling through the phosphatidylinositol-3-kinase–Akt pathway. We have demonstrated that subtle decreases in PTEN abundance can have critical consequences for tumorigenesis. Here, we used a comput...

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Detalhes bibliográficos
Principais autores: Poliseno, Laura, Salmena, Leonardo, Riccardi, Luisa, Fornari, Alessandro, Song, Min Sup, Hobbs, Robin M., Sportoletti, Paolo, Varmeh, Shorheh, Egia, Ainara, Fedele, Giuseppe, Rameh, Lucia, Loda, Massimo, Pandolfi, Pier Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2982149/
https://ncbi.nlm.nih.gov/pubmed/20388916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000594
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