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Immunoglobulin double-isotype expression by trans-mRNA in a human immunoglobulin transgenic mouse.

We have studied immunoglobulin double-isotype expression in a transgenic mouse (TG.SA) in which expression of the endogenous immunoglobulin heavy chain locus is almost completely excluded by a nonallelic rearranged human mu transgene. By flow-cytometric analyses, we have shown that a small, but sign...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Shimizu, A, Nussenzweig, M C, Mizuta, T R, Leder, P, Honjo, T
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298205/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2510157/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.20.8020
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