Immunoglobulin double-isotype expression by trans-mRNA in a human immunoglobulin transgenic mouse.

We have studied immunoglobulin double-isotype expression in a transgenic mouse (TG.SA) in which expression of the endogenous immunoglobulin heavy chain locus is almost completely excluded by a nonallelic rearranged human mu transgene. By flow-cytometric analyses, we have shown that a small, but sign...

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Autori principali: Shimizu, A, Nussenzweig, M C, Mizuta, T R, Leder, P, Honjo, T
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1989
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC298205/
https://ncbi.nlm.nih.gov/pubmed/2510157
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