Targeting of the Orphan Receptor GPR35 by Pamoic Acid: A Potent Activator of Extracellular Signal-Regulated Kinase and β-Arrestin2 with Antinociceptive Activity

Known agonists of the orphan receptor GPR35 are kynurenic acid, zaprinast, 5-nitro-2-(3-phenylproplyamino) benzoic acid, and lysophosphatidic acids. Their relatively low affinities for GPR35 and prominent off-target effects at other pathways, however, diminish their utility for understanding GPR35 s...

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Dades bibliogràfiques
Autors principals: Zhao, Pingwei, Sharir, Haleli, Kapur, Ankur, Cowan, Alan, Geller, Ellen B., Adler, Martin W., Seltzman, Herbert H., Reggio, Patricia H., Heynen-Genel, Susanne, Sauer, Michelle, Chung, Thomas D.Y., Bai, Yushi, Chen, Wei, Caron, Marc G., Barak, Larry S., Abood, Mary E.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2010
Matèries:
Accelerated Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981393/
https://ncbi.nlm.nih.gov/pubmed/20826425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.066746
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