Ultra-Performance Liquid Chromatography Mass Spectrometry and Sensitive Bioassay Methods for Quantification of Posaconazole Plasma Concentrations after Oral Dosing

Posaconazole (POS) is a new antifungal agent for prevention and therapy of mycoses in immunocompromised patients. Variable POS pharmacokinetics after oral dosing may influence efficacy: a trough threshold of 0.5 μg/ml has been recently proposed. Measurement of POS plasma concentrations by complex ch...

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Main Authors: Rochat, Bertrand, Pascual, Andres, Pesse, Benoît, Lamoth, Frédéric, Sanglard, Dominique, Decosterd, Laurent A., Bille, Jacques, Marchetti, Oscar
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Assuntos:
Analytical Procedures
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981256/
https://ncbi.nlm.nih.gov/pubmed/20921320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00022-10
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