Effect of Antacids on the Pharmacokinetics of Raltegravir in Human Immunodeficiency Virus-Seronegative Volunteers

Raltegravir's divalent metal ion chelating motif may predispose the drug to interactions with divalent cations. We determined whether a divalent cation-containing antacid interacted with raltegravir. Twelve HIV-1-seronegative subjects were enrolled in this randomized, prospective, crossover stu...

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Main Authors: Kiser, Jennifer J., Bumpass, J. Brock, Meditz, Amie L., Anderson, Peter L., Bushman, Lane, Ray, Michelle, Predhomme, Julie A., Rower, Joseph, MaWhinney, Sam, Brundage, Richard
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981249/
https://ncbi.nlm.nih.gov/pubmed/20921313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00636-10
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