Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.

We have analyzed the modulation of amyloid beta-protein precursor (APP) gene expression in human umbilical vein endothelial cells (HUVEC). The level of the APP mRNA transcripts increased as HUVEC reached confluency. In confluent culture the half-life of the APP mRNA was 4 hr. Treatment of the cells...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Goldgaber, D, Harris, H W, Hla, T, Maciag, T, Donnelly, R J, Jacobsen, J S, Vitek, M P, Gajdusek, D C
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1989
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298115/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2508093/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.19.7606
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