Type 1 IGF receptor translocates to the nucleus of human tumor cells

The type 1 insulin-like growth factor receptor (IGF-1R) is a transmembrane glycoprotein comprising two extracellular α subunits and two β subunits with tyrosine kinase activity. The IGF-1R is frequently upregulated in cancers, and signals from the cell surface to promote proliferation and cell survi...

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Main Authors: Aleksic, Tamara, Chitnis, Meenali M., Perestenko, Olga V., Gao, Shan, Thomas, Peter H., Turner, Gareth D., Protheroe, Andrew S., Howarth, Mark, Macaulay, Valentine M.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981028/
https://ncbi.nlm.nih.gov/pubmed/20710042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0052
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