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On the Roles of Substrate Binding and Hinge Unfolding in Conformational Changes of Adenylate Kinase

We characterized the conformational change of adenylate kinase (AK) between open and closed forms by conducting five all-atom molecular-dynamics simulations, each of 100 ns duration. Different initial structures and substrate binding configurations were used to probe the pathways of AK conformationa...

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Detalles Bibliográficos
Main Authors: Brokaw, Jason B., Chu, Jhih-Wei
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2010
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980752/
https://ncbi.nlm.nih.gov/pubmed/21081091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.09.040
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