Conformational Changes in Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase upon Substrate Binding: ROLE OF N-TERMINAL LOBE AND ENANTIOMERIC SUBSTRATE PREFERENCE

Inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IP(5) 2-K) catalyzes the synthesis of inositol 1,2,3,4,5,6-hexakisphosphate from ATP and IP(5). Inositol 1,2,3,4,5,6-hexakisphosphate is implicated in crucial processes such as mRNA export, DNA editing, and phosphorus storage in plants. We previously so...

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Detalhes bibliográficos
Main Authors: Baños-Sanz, José Ignacio, Sanz-Aparicio, Julia, Whitfield, Hayley, Hamilton, Chris, Brearley, Charles A., González, Beatriz
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436203/
https://ncbi.nlm.nih.gov/pubmed/22745128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.363671
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