Polycystic kidney disease in Han:SPRD Cy rats is associated with elevated expression and mislocalization of SamCystin

Polycystic kidney disease (PKD) in Han:SPRD Cy rats is caused by a missense mutation in Anks6 (also called Pkdr1), leading to an R823W substitution in SamCystin, a protein that contains ankyrin repeats and a sterile alpha motif (SAM). The cellular function of SamCystin and the role of the Cy (R823W)...

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Main Authors: Nagao, Shizuko, Morita, Miwa, Kugita, Masanori, Yoshihara, Daisuke, Yamaguchi, Tamio, Kurahashi, Hiroki, Calvet, James P., Wallace, Darren P.
格式: Artigo
語言:Inglês
出版: American Physiological Society 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980402/
https://ncbi.nlm.nih.gov/pubmed/20719982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00504.2009
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