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Retroviral vector-mediated high-efficiency expression of adenosine deaminase (ADA) in hematopoietic long-term cultures of ADA-deficient marrow cells.

Two recombinant retroviral vectors encoding the cDNA of the human adenosine deaminase (ADA; EC 3.5.4.4) gene and the bacterial neomycin resistance (Neo) gene have been used to transduce bone marrow cells obtained from four patients affected by the ADA-deficient variant of severe combined immunodefic...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Bordignon, C, Yu, S F, Smith, C A, Hantzopoulos, P, Ungers, G E, Keever, C A, O'Reilly, R J, Gilboa, E
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 1989
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297923/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2549545/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.17.6748
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