Development of a Resistance-like Phenotype to Sorafenib by Human Hepatocellular Carcinoma Cells Is Reversible and Can Be Delayed by Metronomic UFT Chemotherapy

Acquired resistance to antiangiogenic drugs, such as sorafenib, is a major clinical problem. We studied development of a resistance to sorafenib in new preclinical models of human hepatocellular carcinoma (HCC) along with a strategy to delay such resistance—combination with metronomic chemotherapy....

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Main Authors: Tang, Terence C, Man, Shan, Xu, Ping, Francia, Giulio, Hashimoto, Kae, Emmenegger, Urban, Kerbel, Robert S
Formáid: Artigo
Teanga:Inglês
Foilsithe: Neoplasia Press Inc. 2010
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978915/
https://ncbi.nlm.nih.gov/pubmed/21076618
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