Clinical Expression of LRRK2 G2019S Mutations in the Elderly

Mutations in the leucine-rich repeat kinase 2 gene (LRRK2, PARK8) are the most commonly identified monogenic etiology of Parkinson disease (PD). Over-represented in the Ashkenazi Jewish (AJ) population, these mutations are transmitted in an autosomal dominant manner with age-dependent reduced penetr...

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Bibliografiska uppgifter
Huvudupphovsmän: Luciano, Marta San, Lipton, Richard B., Wang, Cuiling, Katz, Mindy, Zimmerman, Molly E., Sanders, Amy E., Ozelius, Laurie J., Bressman, Susan B., Saunders-Pullman, Rachel
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978804/
https://ncbi.nlm.nih.gov/pubmed/20721910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.23330
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