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Targeted Delivery of Saporin Toxin by Monoclonal Antibody to the Transcobalamin Receptor, TCblR/CD320
Cellular uptake of cobalamin (Cbl) occurs by endocytosis of transcobalamin (TC) saturated with Cbl by the transcobalamin receptor (TCblR/CD320). The cell cycle associated over expression of this receptor in many cancer cells, provides a suitable target for delivering chemotherapeutic drugs and cytot...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2978776/ https://ncbi.nlm.nih.gov/pubmed/20858723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0513 |
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