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Targeted Delivery of Saporin Toxin by Monoclonal Antibody to the Transcobalamin Receptor, TCblR/CD320

Cellular uptake of cobalamin (Cbl) occurs by endocytosis of transcobalamin (TC) saturated with Cbl by the transcobalamin receptor (TCblR/CD320). The cell cycle associated over expression of this receptor in many cancer cells, provides a suitable target for delivering chemotherapeutic drugs and cytot...

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Detalhes bibliográficos
Main Authors: Quadros, Edward V., Nakayama, Yasumi, Sequeira, Jeffrey M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978776/
https://ncbi.nlm.nih.gov/pubmed/20858723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0513
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