Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41

The conserved internal trimeric coiled-coil of the N-heptad repeat (N-HR) of HIV-1 gp41 is transiently exposed during the fusion process by forming a pre-hairpin intermediate, thus representing an attractive target for the design of fusion inhibitors and neutralizing antibodies. In previous studies...

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Detalhes bibliográficos
Main Authors: Gustchina, Elena, Li, Mi, Louis, John M., Anderson, D. Eric, Lloyd, John, Frisch, Christian, Bewley, Carole A., Gustchina, Alla, Wlodawer, Alexander, Clore, G. Marius
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978731/
https://ncbi.nlm.nih.gov/pubmed/21085615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001182
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