Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutralization potency and breadth

Previously we reported a broadly HIV-1 neutralizing mini-antibody (Fab 3674) of modest potency that was derived from a human non-immune phage library by panning against the chimeric gp41-derived construct N(CCG)-gp41. This construct presents the N-heptad repeat of the gp41 ectodomain as a stable, he...

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Detalhes bibliográficos
Main Authors: Gustchina, Elena, Louis, John M., Frisch, Christian, Ylera, Francisco, Lechner, Annette, Bewley, Carole A., Clore, G. Marius
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759307/
https://ncbi.nlm.nih.gov/pubmed/19695655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2009.07.019
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