Complexes of Neutralizing and Non-Neutralizing Affinity Matured Fabs with a Mimetic of the Internal Trimeric Coiled-Coil of HIV-1 gp41

A series of mini-antibodies (monovalent and bivalent Fabs) targeting the conserved internal trimeric coiled-coil of the N-heptad repeat (N-HR) of HIV-1 gp41 has been previously constructed and reported. Crystal structures of two closely related monovalent Fabs, one (Fab 8066) broadly neutralizing ac...

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Detalhes bibliográficos
Main Authors: Gustchina, Elena, Li, Mi, Ghirlando, Rodolfo, Schuck, Peter, Louis, John M., Pierson, Jason, Rao, Prashant, Subramaniam, Sriram, Gustchina, Alla, Clore, G. Marius, Wlodawer, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820714/
https://ncbi.nlm.nih.gov/pubmed/24244293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078187
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