Differential proteolytic activation of factor VIII-von Willebrand factor complex by thrombin.
Blood coagulation factor VIII (fVIII) is a plasma protein that is decreased or absent in hemophilia A. It is isolated as a mixture of heterodimers that contain a variably sized heavy chain and a common light chain. Thrombin catalyzes the activation of fVIII in a reaction that is associated with clea...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1989
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297873/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2505252/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.17.6508 |
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