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Hsp90 Interaction with INrf2(Keap1) Mediates Stress-induced Nrf2 Activation
INrf2(Keap1) functions as an adapter for Cul3/Rbx1-mediated degradation of Nrf2. In response to stress, Nrf2 is released from INrf2 and translocates inside the nucleus leading to activation of cytoprotective proteins critical in protection against adverse effects including cancer. We demonstrate her...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Biochemistry and Molecular Biology
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2978616/ https://ncbi.nlm.nih.gov/pubmed/20864537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.175802 |
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