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Prothymosin-α Mediates Nuclear Import of the INrf2/Cul3·Rbx1 Complex to Degrade Nuclear Nrf2
Nrf2-mediated coordinated induction of a battery of defensive genes is a critical mechanism in cellular protection and survival. INrf2 (Keap1), an inhibitor of Nrf2, functions as an adaptor for Cul3·Rbx1-mediated degradation of Nrf2. A majority of the INrf2/Cul3·Rbx1 complex is localized in the cyto...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2679486/ https://ncbi.nlm.nih.gov/pubmed/19279002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808084200 |
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