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Antioxidant-induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2–Cul3–Rbx1 complex to allow normal Nrf2 activation and repression

INrf2 (Keap1) serves as a negative regulator of the cytoprotective transcription factor Nrf2. At basal levels, INrf2 functions as a substrate adaptor to sequester Nrf2 into the Cul3–Rbx1 E3 ligase complex for ubiquitylation and proteasomal degradation. In response to antioxidants, Nrf2 is released f...

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書誌詳細
主要な著者: Kaspar, James W., Niture, Suryakant K., Jaiswal, Anil K.
フォーマット: Artigo
言語:Inglês
出版事項: Company of Biologists 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311933/
https://ncbi.nlm.nih.gov/pubmed/22448038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.097295
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