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Oncogene PKCε controls INrf2–Nrf2 interaction in normal and cancer cells through phosphorylation of INrf2

The INrf2 (Keap1)–Nrf2 cell sensor complex has a crucial role in protection against chemical- and radiation-induced oxidative stress and cellular transformation. INrf2, in association with Cul3–Rbx1, ubiquitylates and degrades Nrf2. Exposure to stressors leads to stabilization of Nrf2 and the coordi...

詳細記述

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書誌詳細
主要な著者: Niture, Suryakant K., Gnatt, Averell, Jaiswal, Anil K.
フォーマット: Artigo
言語:Inglês
出版事項: The Company of Biologists 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3860311/
https://ncbi.nlm.nih.gov/pubmed/24127568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.133819
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