O-Glycosylation Modulates Proprotein Convertase Activation of Angiopoietin-like Protein 3: POSSIBLE ROLE OF POLYPEPTIDE GalNAc-TRANSFERASE-2 IN REGULATION OF CONCENTRATIONS OF PLASMA LIPIDS

The angiopoietin-like protein 3 (ANGPTL3) is an important inhibitor of the endothelial and lipoprotein lipases and a promising drug target. ANGPTL3 undergoes proprotein convertase processing (RAPR(224)↓TT) for activation, and the processing site contains two potential GalNAc O-glycosylation sites im...

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Main Authors: Schjoldager, Katrine T.-B. G., Vester-Christensen, Malene B., Bennett, Eric Paul, Levery, Steven B., Schwientek, Tilo, Yin, Wu, Blixt, Ola, Clausen, Henrik
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Glycobiology and Extracellular Matrices
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978557/
https://ncbi.nlm.nih.gov/pubmed/20837471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.156950
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