Small nucleolar RNA interference in Trypanosoma brucei: mechanism and utilization for elucidating the function of snoRNAs

Expression of dsRNA complementary to small nucleolar RNAs (snoRNAs) in Trypanosoma brucei results in snoRNA silencing, termed snoRNAi. Here, we demonstrate that snoRNAi requires the nuclear TbDCL2 protein, but not TbDCL1, which is involved in RNA interference (RNAi) in the cytoplasm. snoRNAi depends...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Gupta, Sachin Kumar, Hury, Avraham, Ziporen, Yaara, Shi, Huafang, Ullu, Elisabetta, Michaeli, Shulamit
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2010
Aiheet:
RNA
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978370/
https://ncbi.nlm.nih.gov/pubmed/20601683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq599
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