Small nucleolar RNA interference in Trypanosoma brucei: mechanism and utilization for elucidating the function of snoRNAs

Expression of dsRNA complementary to small nucleolar RNAs (snoRNAs) in Trypanosoma brucei results in snoRNA silencing, termed snoRNAi. Here, we demonstrate that snoRNAi requires the nuclear TbDCL2 protein, but not TbDCL1, which is involved in RNA interference (RNAi) in the cytoplasm. snoRNAi depends...

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Bibliografiske detaljer
Main Authors: Gupta, Sachin Kumar, Hury, Avraham, Ziporen, Yaara, Shi, Huafang, Ullu, Elisabetta, Michaeli, Shulamit
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
Fag:
RNA
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978370/
https://ncbi.nlm.nih.gov/pubmed/20601683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq599
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