Small nucleolar RNA interference in Trypanosoma brucei: mechanism and utilization for elucidating the function of snoRNAs

Expression of dsRNA complementary to small nucleolar RNAs (snoRNAs) in Trypanosoma brucei results in snoRNA silencing, termed snoRNAi. Here, we demonstrate that snoRNAi requires the nuclear TbDCL2 protein, but not TbDCL1, which is involved in RNA interference (RNAi) in the cytoplasm. snoRNAi depends...

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Bibliografske podrobnosti
Main Authors: Gupta, Sachin Kumar, Hury, Avraham, Ziporen, Yaara, Shi, Huafang, Ullu, Elisabetta, Michaeli, Shulamit
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2010
Teme:
RNA
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978370/
https://ncbi.nlm.nih.gov/pubmed/20601683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq599
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