The large repertoire of 2’-O-methylation guided by C/D snoRNAs on Trypanosoma brucei rRNA

The parasite Trypanosoma brucei cycles between insect and mammalian hosts, and is the causative agent of sleeping sickness. Here, we performed genome-wide mapping of 2ʹ-O-methylations (Nms) on trypanosome rRNA using three high-throughput sequencing methods; RibOxi-seq, RiboMeth-seq and 2ʹ-OMe-seq. T...

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Veröffentlicht in:RNA Biol
Hauptverfasser: Rajan, K. Shanmugha, Zhu, Yinzhou, Adler, Katerina, Doniger, Tirza, Cohen-Chalamish, Smadar, Srivastava, Ankita, Shalev-Benami, Moran, Matzov, Donna, Unger, Ron, Tschudi, Christian, Günzl, Arthur, Carmichael, Gordon G., Michaeli, Shulamit
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549662/
https://ncbi.nlm.nih.gov/pubmed/32250712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2020.1750842
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