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Subtle gene modification in mouse ES cells: evidence for incorporation of unmodified oligonucleotides without induction of DNA damage
Gene targeting by single-stranded oligodeoxyribonucleotides (ssODNs) is a promising tool for site-specific gene modification in mouse embryonic stem cells (ESCs). We have developed an ESC line carrying a mutant EGFP reporter gene to monitor gene correction events shortly after exposure to ssODNs. We...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2010
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2978364/ https://ncbi.nlm.nih.gov/pubmed/20601408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq589 |
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