Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives

Neuronal nitric oxide synthase (nNOS) represents an important therapeutic target for the prevention of brain injury and the treatment of various neurodegenerative disorders. A series of trans substituted amino pyrrolidinomethyl 2-aminopyridine derivatives (8–34) was designed and synthesized. A struc...

Full description

Saved in:
Bibliographic Details
Main Authors: Ji, Haitao, Delker, Silvia L., Li, Huiying, Martásek, Pavel, Roman, Linda J., Poulos, Thomas L., Silverman, Richard B.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978073/
https://ncbi.nlm.nih.gov/pubmed/20958055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100947x
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items