Llwytho...

Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives

Neuronal nitric oxide synthase (nNOS) represents an important therapeutic target for the prevention of brain injury and the treatment of various neurodegenerative disorders. A series of trans substituted amino pyrrolidinomethyl 2-aminopyridine derivatives (8–34) was designed and synthesized. A struc...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ji, Haitao, Delker, Silvia L., Li, Huiying, Martásek, Pavel, Roman, Linda J., Poulos, Thomas L., Silverman, Richard B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978073/
https://ncbi.nlm.nih.gov/pubmed/20958055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100947x
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