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Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives

Neuronal nitric oxide synthase (nNOS) represents an important therapeutic target for the prevention of brain injury and the treatment of various neurodegenerative disorders. A series of trans substituted amino pyrrolidinomethyl 2-aminopyridine derivatives (8–34) was designed and synthesized. A struc...

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Bibliografiske detaljer
Main Authors: Ji, Haitao, Delker, Silvia L., Li, Huiying, Martásek, Pavel, Roman, Linda J., Poulos, Thomas L., Silverman, Richard B.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978073/
https://ncbi.nlm.nih.gov/pubmed/20958055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100947x
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