High-Throughput, Sensitive Quantification of Repopulating Hematopoietic Stem Cell Clones

Retroviral vector-mediated gene therapy has been successfully used to correct genetic diseases. However, a number of studies have shown a subsequent risk of cancer development or aberrant clonal growths due to vector insertion near or within proto-oncogenes. Recent advances in the sequencing technol...

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Detalhes bibliográficos
Main Authors: Kim, Sanggu, Kim, Namshin, Presson, Angela P., An, Dong Sung, Mao, Si Hua, Bonifacino, Aylin C., Donahue, Robert E., Chow, Samson A., Chen, Irvin S. Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Gene Delivery
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2977897/
https://ncbi.nlm.nih.gov/pubmed/20844053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01355-10
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