Extracellular 2′-5′ Oligoadenylate Synthetase Stimulates RNase L-Independent Antiviral Activity: a Novel Mechanism of Virus-Induced Innate Immunity

The 2′-5′ oligoadenylate synthetase (OAS) proteins are traditionally considered intracellular antiviral proteins. However, several studies demonstrate a correlation between the concentration of freely circulating OAS protein in sera from hepatitis C patients and their clinical prognosis. Here we dem...

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Autori principali: Kristiansen, Helle, Scherer, Christina A., McVean, Maralee, Iadonato, Shawn P., Vends, Susanne, Thavachelvam, Karthiga, Steffensen, Thomas B., Horan, Kristy A., Kuri, Thomas, Weber, Friedemann, Paludan, Søren R., Hartmann, Rune
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
Soggetti:
Cellular Response to Infection
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2977878/
https://ncbi.nlm.nih.gov/pubmed/20844035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01003-10
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