Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone.

Islet amyloid polypeptide (IAPP) is a 37-amino acid peptide found in the pancreatic amyloid deposits of type II (non-insulin-dependent) diabetic patients and insulinomas. We previously reported the nucleotide sequence of a human cDNA, which indicated that IAPP is a C-terminally amidated peptide deri...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Nishi, M, Chan, S J, Nagamatsu, S, Bell, G I, Steiner, D F
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297705/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2668946/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.15.5738
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