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Design and Optimization of Mefloquine Hydrochloride Microparticles for Bitter Taste Masking
The objective of the present investigation was to reduce the bitterness with improved dissolution, in acidic medium (pH 1.2), of mefloquine hydrochloride (MFL). Microparticles were prepared by coacervation method using Eudragit E (EE) as polymer and sodium hydroxide as precipitant. A 3(2) full facto...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Springer US
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2976944/ https://ncbi.nlm.nih.gov/pubmed/18431670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-008-9052-x |
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