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Design and Optimization of Mefloquine Hydrochloride Microparticles for Bitter Taste Masking
The objective of the present investigation was to reduce the bitterness with improved dissolution, in acidic medium (pH 1.2), of mefloquine hydrochloride (MFL). Microparticles were prepared by coacervation method using Eudragit E (EE) as polymer and sodium hydroxide as precipitant. A 3(2) full facto...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2976944/ https://ncbi.nlm.nih.gov/pubmed/18431670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-008-9052-x |
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