Evidence that brain prostaglandin E2 is involved in physiological sleep-wake regulation in rats.

We reported in previous studies that prostaglandin E2 (PGE2) has central effects of augmenting wakefulness and suppressing slow-wave sleep (SWS) and paradoxical sleep (PS) in rats. In the present study, we tested the effect of AH 6809, an antagonist of PGE2 receptors, on sleep-wake activities. AH 68...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Matsumura, H, Honda, K, Choi, W S, Inoué, S, Sakai, T, Hayaishi, O
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1989
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297685/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2748610/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.14.5666
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