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The Aging-Associated Enzyme CLK-1 is a Member of the Carboxylate-Bridged Diiron Family of Proteins

The aging-associated enzyme CLK-1 is proposed to be a member of the carboxylate-bridged diiron family of proteins. To evaluate this hypothesis and characterize the protein, we expressed soluble mouse CLK-1 (MCLK1) in E. coli as a heterologous host. Using Mössbauer and EPR spectroscopy, we establishe...

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Detalhes bibliográficos
Main Authors: Behan, Rachel K., Lippard, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976817/
https://ncbi.nlm.nih.gov/pubmed/20923139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101475z
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