α-TEA-induced death receptor dependent apoptosis involves activation of acid sphingomyelinase and elevated ceramide-enriched cell surface membranes

BACKGROUND: Alpha-tocopherol ether-linked acetic acid (α-TEA), an analog of vitamin E (RRR-alpha-tocopherol), is a potent and selective apoptosis-inducing agent for human cancer cells in vivo and in vitro. α-TEA induces apoptosis via activation of extrinsic death receptors Fas (CD95) and DR5, JNK/p7...

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Detalhes bibliográficos
Principais autores: Li, Jing, Yu, Weiping, Tiwary, Richa, Park, Sook-Kyung, Xiong, Ailian, Sanders, Bob G, Kline, Kimberly
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Primary Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976739/
https://ncbi.nlm.nih.gov/pubmed/20974006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-10-40
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