A carregar...
Significant structural and functional change of an antigen-binding site by a distant amino acid substitution: proposal of a structural mechanism.
To study the molecular basis for antibody diversity and the structural basis for antigen binding, we have characterized the loss of phosphocholine (P-Cho) binding both experimentally and computationally in U10, a somatic mutant of the antibody S107. Nucleotide sequencing of U10 shows a single base c...
Na minha lista:
| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1989
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297657/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2748602/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.14.5532 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|