Significant structural and functional change of an antigen-binding site by a distant amino acid substitution: proposal of a structural mechanism.
To study the molecular basis for antibody diversity and the structural basis for antigen binding, we have characterized the loss of phosphocholine (P-Cho) binding both experimentally and computationally in U10, a somatic mutant of the antibody S107. Nucleotide sequencing of U10 shows a single base c...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
1989
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297657/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2748602/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.14.5532 |
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