Significant structural and functional change of an antigen-binding site by a distant amino acid substitution: proposal of a structural mechanism.

To study the molecular basis for antibody diversity and the structural basis for antigen binding, we have characterized the loss of phosphocholine (P-Cho) binding both experimentally and computationally in U10, a somatic mutant of the antibody S107. Nucleotide sequencing of U10 shows a single base c...

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Bibliographic Details
Main Authors: Chien, N C, Roberts, V A, Giusti, A M, Scharff, M D, Getzoff, E D
Format: Artigo
Language:Inglês
Published: 1989
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC297657/
https://ncbi.nlm.nih.gov/pubmed/2748602
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