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Significant structural and functional change of an antigen-binding site by a distant amino acid substitution: proposal of a structural mechanism.

To study the molecular basis for antibody diversity and the structural basis for antigen binding, we have characterized the loss of phosphocholine (P-Cho) binding both experimentally and computationally in U10, a somatic mutant of the antibody S107. Nucleotide sequencing of U10 shows a single base c...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Chien, N C, Roberts, V A, Giusti, A M, Scharff, M D, Getzoff, E D
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297657/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2748602/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.14.5532
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