Should Moxifloxacin Be Used for the Treatment of Extensively Drug-Resistant Tuberculosis? An Answer from a Murine Model

The prevalence of extensively drug-resistant tuberculosis (XDR-TB), defined as TB that is resistant to isoniazid, rifampin, fluoroquinolones, and aminoglycosides, is rising worldwide. The extent of Mycobacterium tuberculosis resistance to fluoroquinolones depends on the mutation in the DNA gyrase, t...

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Bibliographic Details
Main Authors: Poissy, Julien, Aubry, Alexandra, Fernandez, Christine, Lott, Marie-Catherine, Chauffour, Aurelie, Jarlier, Vincent, Farinotti, Robert, Veziris, Nicolas
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976119/
https://ncbi.nlm.nih.gov/pubmed/20805388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00968-10
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