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Characterization of the Human Pancreatic Islet Proteome by Two-Dimensional LC/MS/MS

The pancreatic beta-cell plays a central role in the maintenance of glucose homeostasis and in the pathogenesis of both type 1 and type 2 diabetes mellitus. Elucidation of the insulin secretory defects observed in diabetes first requires a better understanding of the complex mechanisms regulating in...

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Hlavní autoři: Metz, Thomas O., Jacobs, Jon M., Gritsenko, Marina A., Fontès, Ghislaine, Qian, Wei-Jun, Camp, David G., Poitout, Vincent, Smith, Richard D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975945/
https://ncbi.nlm.nih.gov/pubmed/17137336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr060322n
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