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Influenza A virus strains that circulate in humans differ in the ability of their NS1 proteins to block the activation of IRF3 and interferon-β transcription

We demonstrate that influenza A virus strains that circulate in humans differ markedly in the ability of their NS1 proteins to block the activation of IRF3 and interferon-β transcription. Strong activation occurs in cells infected with viruses expressing NS1 proteins of seasonal H3N2 and H2N2 viruse...

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Detalhes bibliográficos
Main Authors: Kuo, Rei-Lin, Zhao, Chen, Malur, Meghana, Krug, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975781/
https://ncbi.nlm.nih.gov/pubmed/20934196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.09.012
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