Selective displacement of nuclear proteins by antitumor drugs having affinity for nucleic acids.

The nuclear chromatin binding sites of the antitumor drugs mitoxantrone, ametantrone, doxorubicin, mithramycin, and actinomycin D and the intercalating ligand ethidium were studied by polyacrylamide gel electrophoresis of the proteins released from rat liver nuclei in the presence and absence of the...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Bartkowiak, J, Kapuscinski, J, Melamed, M R, Darzynkiewicz, Z
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1989
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297575/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2525781/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.13.5151
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