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Selective displacement of nuclear proteins by antitumor drugs having affinity for nucleic acids.

The nuclear chromatin binding sites of the antitumor drugs mitoxantrone, ametantrone, doxorubicin, mithramycin, and actinomycin D and the intercalating ligand ethidium were studied by polyacrylamide gel electrophoresis of the proteins released from rat liver nuclei in the presence and absence of the...

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Bibliografische gegevens
Hoofdauteurs: Bartkowiak, J, Kapuscinski, J, Melamed, M R, Darzynkiewicz, Z
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1989
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC297575/
https://ncbi.nlm.nih.gov/pubmed/2525781
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