Multimodal Imaging of Integrin Receptor-Positive Tumors by Bioluminescence, Fluorescence, Gamma Scintigraphy and SPECT Methods Using a Cyclic RGD Peptide Labeled with a Near Infrared Fluorescent Dye and a Radionuclide

Integrins, particularly the α(v)β(3) heterodimers, play important roles in tumor-induced angiogenesis and invasiveness. To image the expression pattern of the α(v)β(3) integrin in tumors through a multimodality imaging paradigm, we prepared a cyclic RGDyK peptide analog (LS308) bearing a tetraazamac...

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Hlavní autoři: Edwards, W. Barry, Akers, Walter J., Ye, Yunpeng, Cheney, Phillip P., Bloch, Sharon, Laforest, Richard, Achilefu, Samuel
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975541/
https://ncbi.nlm.nih.gov/pubmed/19397855
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