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Chronic Alcohol-Induced Liver Injury and Oxidant Stress is Decreased in Cytochrome P4502E1 Knockout Mice and Restored in Humanized Cytochrome P4502E1 Knockin Mice
A major pathway for chronic ethanol-induced liver injury is ethanol-induced oxidant stress. Several pathways contribute to mechanisms by which ethanol induces oxidant stress. While some studies support a role for cytochrome P450 2E1 (CYP2E1), others do not. Most previous studies were conducted in th...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2975513/ https://ncbi.nlm.nih.gov/pubmed/20692331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.07.026 |
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